Реакция #161492

Уравнение реакции

water

potassium carbonate

1-(2-aminoethyl)piperidine

2-(4-fluoro-3-nitrophenyl)benzoxazole

→

title compound

Выход 94.0%

N-(2-(piperidin-1-yl)ethyl)-4-(benzoxazol-2-yl)-2-nitroaniline

Выход 94.0%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   Температураthis was heated
2. 2
   Температураto reflux for 3 hours
3. 3
   Фильтрацияafter the precipitated crystals were filtered
4. 4
   Промывкаwashed with water, they
5. 5
   Другоеwere dried

Методика

To a suspension of 2-(4-fluoro-3-nitrophenyl)benzoxazole (see Working Example 15-2) (200 mg, 0.775 mmol) in acetonitrile (5 mL) was added potassium carbonate (214 mg, 1.55 mmol) and 1-(2-aminoethyl)piperidine (119 mg, 0.93 mmol), and this was heated to reflux for 3 hours. After the reaction was complete, this was cooled to room temperature, water was added, and after the precipitated crystals were filtered and washed with water, they were dried to yield the title compound (266 mg, 94% yield) as yellow crystals.

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