Реакция #161476

Уравнение реакции

2-(4-chloro-2-fluoronitrobenzen-5-yl)benzoxazole

4-aminotetrahydropyran

water

→

title compound

Выход 21.0%

2-(4-chloro-2-(tetrahydropyran-4-yl)aminonitrobenzen-5-yl)benzoxazole

Выход 21.0%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   Температураthis was heated
2. 2
   Температураto reflux for 2 hours
3. 3
   Фильтрацияthe precipitated crystals were filtered
4. 4
   ДругоеThe crystals obtained
5. 5
   Другоеwere purified by silica gel column chromatography

Методика

To a suspension of 2-(4-chloro-2-fluoronitrobenzen-5-yl)benzoxazole (see Working Example 112-1) (0.38 g, 1.3 mmol) in acetonitrile (8 mL) was added 4-aminotetrahydropyran (0.30 g, 2.9 mmol), and this was heated to reflux for 2 hours. After the reaction was complete, this was cooled to room temperature, water was added, and the precipitated crystals were filtered. The crystals obtained were purified by silica gel column chromatography to yield the title compound (0.10 g, 21% yield) as brown crystals.

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