Реакция #1614

Уравнение реакции

2-benzyloxyphenol

potassium carbonate

(S)-Glycidyl-3-nitrobenzenesulphonate

→

title compound

(S)-Glycidyl-2-benzyloxyphenol

Растворители

acetone

Условия реакции

Обработка

1. 1
   Температураwas heated
2. 2
   Температураunder reflux for 15 mins
3. 3
   Температураthe reaction mixture was heated
4. 4
   Температураunder reflux for 23 hours
5. 5
   ТемператураAfter cooling
6. 6
   Фильтрацияthe reaction mixture was filtered
7. 7
   Другоеthe solvent was evaporated
8. 8
   ДругоеThe residue was partitioned between ethyl acetate and water
9. 9
   Промывкаwashed with water and brine
10. 10
    Другоеdried
11. 11
    Другоеevaporated

Методика

A mixture of 2-benzyloxyphenol (900 mg, 4.5 mMol) and potassium carbonate (1.87 g, 13.5 mMol) in acetone (45 ml) was heated under reflux for 15 mins. (S)-Glycidyl-3-nitrobenzenesulphonate (1.0 g, 4.5 mMol) was added and the reaction mixture was heated under reflux for 23 hours. After cooling, the reaction mixture was filtered and the solvent was evaporated. The residue was partitioned between ethyl acetate and water. The organic fractions were combined, washed with water and brine, dried and evaporated to give the title compound as an oil.

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