Реакция #161288

Уравнение реакции

N-(1-acetylindolin-6-yl)-4-oxo-1H-quinoline-3-carboxamide

NaOH

→

N-indolin-6-yl-4-oxo-1H-quinoline-3-carboxamide

Выход 27.3%

N-Indolin-6-yl-4-oxo-1H-quinoline-3-carboxamide

Выход 27.3%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   Температураwas heated
2. 2
   Температураto reflux for 48 h
3. 3
   КонцентрированиеThe solution was concentrated
4. 4
   workup.DISSOLUTIONthe residue was dissolved in DMSO (1 mL)
5. 5
   Другоеpurified by HPLC (10-99% CH3CN—H2O)

Методика

A mixture of N-(1-acetylindolin-6-yl)-4-oxo-1H-quinoline-3-carboxamide (233) (43 mg, 0.12 mmol), 1N NaOH solution (0.5 mL) and ethanol (0.5 mL) was heated to reflux for 48 h. The solution was concentrated and the residue was dissolved in DMSO (1 mL) and purified by HPLC (10-99% CH3CN—H2O) to yield the product, N-indolin-6-yl-4-oxo-1H-quinoline-3-carboxamide (258) (10 mg, 20%). HPLC ret. time 2.05 min, 10-99% CH3CN, 5 min run; ESI-MS 306.3 m/z (MH+).

Источник