Реакция #161002

Уравнение реакции

sodium hydroxide

1-[(3-furanylcarbonyl)amino]cyclohexanecarboxylic acid methyl ester

ether

→

title compound

Выход 97.0%

1-[(3-Furanylcarbonyl)amino]cyclohexanecarboxylic acid

Выход 97.0%

Растворители

tetrahydrofuran

Условия реакции

Обработка

1. 1
   Температураthe mixture was heated
2. 2
   Температураunder reflux for 3 hours
3. 3
   Промывкаto wash it
4. 4
   Экстракцияthe mixture was extracted with ethyl acetate
5. 5
   ПромывкаAfter the obtained organic layer was washed with saturated brine, it
6. 6
   Сушкаwas dried with anhydrous sodium sulfate
7. 7
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

Методика

450 ml of 2N aqueous sodium hydroxide solution was added to a solution of 75.4 g (300 mmol) of 1-[(3-furanylcarbonyl)amino]cyclohexanecarboxylic acid methyl ester in 450 ml of tetrahydrofuran, and the mixture was heated under reflux for 3 hours. After ether was added to the reaction solution to wash it, the aqueous layer was neutralized by concentrated hydrochloric acid, and the mixture was extracted with ethyl acetate. After the obtained organic layer was washed with saturated brine, it was dried with anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain 68.8 g (97%) of the title compound.

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