Реакция #1605864

Уравнение реакции

4-propionylbenzenesulfonamide

DMF

N,N-dimethylformamidedimethyl acetal

→

title compound

Выход 94.0%

N,N-dimethyl-N′-((4-propionylphenyl)sulfonyl) formimidamide

Выход 94.0%

Растворители

ethylacetate

Условия реакции

Обработка

1. 1
   КонцентрированиеThe reaction mixture was concentrated under reduced pressure
2. 2
   Другоеto obtain a solid product, which
3. 3
   Промывкаwas washed with diisopropylether

Методика

To a stirred solution of 4-propionylbenzenesulfonamide (prepared according to the procedure reported in Bioorganic Chemistry 1994, 22, 387-394), 2.2 g (10.3 mmol) in ethylacetate (20 ml) was added DMF (2.0 ml) followed by the addition of N,N-dimethylformamidedimethyl acetal (1.36 g, 1.51 ml, 11.36 mmol) in a dropwise manner at room temperature. The resulting mixture was stirred at room temperature for 4 hr. The progress of the reaction was monitored by TLC. The reaction mixture was concentrated under reduced pressure to obtain a solid product, which was washed with diisopropylether to obtain the title compound (2.6 g, 94%).

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