Реакция #1605856

Уравнение реакции

water

p-methoxybenzyl chloride

methanesulfonamide

potassium carbonate

→

title compound

Выход 97.0%

N,N-bis(4-methoxybenzyl)methanesulfonamide

Выход 97.0%

Растворители

N,N-dimethylformamide

Условия реакции

Обработка

1. 1
   Другоеthe resultant reaction mixture
2. 2
   Другоеthe resultant reaction mixture
3. 3
   workup.STIRRINGwas stirred at room temperature for 19 hours
4. 4
   Экстракцияthe mixture was extracted with ethyl acetate
5. 5
   СушкаThe obtained organic phase was dried over anhydrous sodium sulfate
6. 6
   workup.DISTILLATIONFrom the organic phase, the solvent was distilled off under reduced pressure

Методика

To a solution of methanesulfonamide (5 g) in N,N-dimethylformamide (75 mL), potassium carbonate (29.1 g) was added and the resultant reaction mixture was stirred at room temperature for 5 hours. To the solution, p-methoxybenzyl chloride (18.1 g) was added and the resultant reaction mixture was stirred at room temperature for 19 hours. To the reaction solution, water was added and the mixture was extracted with ethyl acetate. The obtained organic phase was dried over anhydrous sodium sulfate. From the organic phase, the solvent was distilled off under reduced pressure to give the title compound (17.1 g) as a white solid.

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