Реакция #1605844

Уравнение реакции

pivaloyl chloride

dehydro-aripiprazole

pyridine

→

7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2-yl pivalate

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   Промывкаwashed with water
2. 2
   Сушкаdried over MgSO4
3. 3
   ДругоеAfter evaporation the residue
4. 4
   Другоеfurther purified on silica eluting with ethyl acetate
5. 5
   ДругоеAfter evaporation of the product
6. 6
   workup.ADDITIONcontaining fraction
7. 7
   ДругоеCompound-316 (0.53 g) was obtained as a colourless oil

Методика

To a solution of dehydro-aripiprazole (1.2 g, 2.7 mmol) in dichloromethane (30 mL) was added pyridine (1 mL), followed by pivaloyl chloride (0.66 mL, 5.4 mmol). The reaction mixture was stirred for 20 hours, then washed with water and dried over MgSO4. After evaporation the residue was co-evaporated with toluene and then further purified on silica eluting with ethyl acetate. After evaporation of the product containing fraction, Compound-316 (0.53 g) was obtained as a colourless oil.

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