Реакция #1605841

Уравнение реакции

dibenzylcarbamoyl chloride

dehydro-aripiprazole

→

7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2-yl dibenzylcarbamate

Растворители

pyridine

Условия реакции

Обработка

1. 1
   Температураthe reaction mixture heated
2. 2
   Температураat reflux for 4 h
3. 3
   КонцентрированиеThe reaction mixture was concentrated
4. 4
   workup.DISSOLUTIONThe residue was dissolved in ethyl acetate (ethyl acetate)
5. 5
   Промывкаwashed with water
6. 6
   Сушкаdried over MgSO4
7. 7
   ДругоеAfter evaporation the residue
8. 8
   Другоеwas further purified on silica eluting with ethyl acetate
9. 9
   Другоеafter drying
10. 10
    Другоеgave Compound-342 (0.71 g) as a white solid

Методика

To a solution of dibenzylcarbamoyl chloride (1.7 g, 6.7 mmol) in pyridine (15 mL) was added dehydro-aripiprazole (1.5 g, 3.4 mmol) and the reaction mixture heated at reflux for 4 h. The reaction mixture was concentrated and the residue co-evaporated with toluene (×3). The residue was dissolved in ethyl acetate (ethyl acetate), washed with water and dried over MgSO4. After evaporation the residue was further purified on silica eluting with ethyl acetate and after drying gave Compound-342 (0.71 g) as a white solid.

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