Реакция #1605833

Уравнение реакции

aripiprazole

triethylamine

ethyl isocyanate

→

7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-N-ethyl-3,4-dihydro-2-oxoquinoline-1(2H)-carboxamide

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   ДругоеThe reaction was quenched with water
2. 2
   Экстракцияextracted with dichloromethane (3×20 mL)
3. 3
   Промывкаwashed with saturated aqueous sodium hydrogen carbonate (20 mL) and brine (20 mL)
4. 4
   Сушкаdried over MgSO4
5. 5
   Концентрированиеconcentrated
6. 6
   ДругоеThe product was purified by column chromatography on silica eluting with 0-3% methanol in 1:1 ethyl acetate to dichloromethane
7. 7
   ДругоеThe product was triturated in heptane
8. 8
   Другоеto remove aliphatic impurities
9. 9
   Фильтрацияfiltered
10. 10
    Другоеdried
11. 11
    workup.DISSOLUTIONThe material was dissolved in ethyl acetate
12. 12
    Промывкаwashed with saturated aqueous sodium hydrogen carbonate (6×15 mL)
13. 13
    Другоеto afford Compound-72 (0.482 g) as a pink solid

Методика

To a solution of aripiprazole (1.5 g, 3.35 mmol) in dichloromethane (33 mL) was added triethylamine (0.56 mL, 4.01 mmol) and ethyl isocyanate (0.53 mL, 6.69 mmol). The reaction was stirred at room temperature for 5 days. The reaction was quenched with water and extracted with dichloromethane (3×20 mL). The organics were combined, washed with saturated aqueous sodium hydrogen carbonate (20 mL) and brine (20 mL), dried over MgSO4 and concentrated. The product was purified by column chromatography on silica eluting with 0-3% methanol in 1:1 ethyl acetate to dichloromethane. The product was triturated in heptane to remove aliphatic impurities and then filtered and dried. The material was dissolved in ethyl acetate and washed with saturated aqueous sodium hydrogen carbonate (6×15 mL) to afford Compound-72 (0.482 g) as a pink solid.

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