Реакция #1605830

Уравнение реакции

2-[(3-nitro-4-phenylphenyl)methyl]-2,3-dihydro-1H-isoindole-1,3-dione

hydrazine monohydrate

→

(3-nitro-4-phenylphenyl)methanamine

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ФильтрацияThe reaction solution was filtered, to the filtrate
2. 2
   workup.ADDITIONwas added 0.6 M hydrochloric acid and ethyl acetate
3. 3
   workup.STIRRINGthe mixture was stirred vigorously
4. 4
   ДругоеThe aqueous layer was separated
5. 5
   Экстракцияextracted with ethyl acetate
6. 6
   ПромывкаThe organic layer was washed with a saturated aqueous solution of sodium chloride
7. 7
   Сушкаdried over anhydrous sodium sulfate
8. 8
   Концентрированиеconcentrated under reduced pressure

Методика

The obtained 2-[(3-nitro-4-phenylphenyl)methyl]-2,3-dihydro-1H-isoindole-1,3-dione was dissolved in ethanol (30 mL), an aqueous solution of hydrazine monohydrate (2 mL) was added thereto, and the mixture was stirred at 70° C. for 1 hour. The reaction solution was filtered, to the filtrate was added 0.6 M hydrochloric acid and ethyl acetate, and the mixture was stirred vigorously. The aqueous layer was separated and, after being neutralized with a 5M aqueous solution of sodium hydroxide, extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to obtain (3-nitro-4-phenylphenyl)methanamine as a crude material (305.5 mg)

Источник