Реакция #1605829

Уравнение реакции

4-(Bromoethyl)-2-nitro-1-phenylbenzene

potassium phthalimide

→

2-[(3-nitro-4-phenylphenyl)methyl]-2,3-dihydro-1H-isoindole-1,3-dione

Выход 83.8%

Растворители

N,N-dimethylformamide

Условия реакции

Обработка

1. 1
   ЭкстракцияThe reaction mixture was extracted with ethyl acetate
2. 2
   Промывкаthe organic layer was washed with a saturated aqueous solution of sodium chloride
3. 3
   Сушкаdried over anhydrous magnesium sulfate
4. 4
   Концентрированиеconcentrated under reduced pressure
5. 5
   ДругоеThe residue was purified by flash column chromatography

Методика

4-(Bromoethyl)-2-nitro-1-phenylbenzene (584.3 mg, 2.0 mmol) and potassium phthalimide (555.0 mg, 3.0 mmol) were dissolved in N,N-dimethylformamide (8 mL) and the mixture was stirred at 110° C. for 3 hours. The reaction mixture was extracted with ethyl acetate and the organic layer was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by flash column chromatography to obtain 2-[(3-nitro-4-phenylphenyl)methyl]-2,3-dihydro-1H-isoindole-1,3-dione (600.8 mg).

Источник