Реакция #1605816

Уравнение реакции

boron tribromide

4-Methoxy-2-nitro-1-phenylbenzene

→

3-nitro-4-phenylphenol

Растворители

dichloromethane

dichloromethane

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added, under ice-water cooling
2. 2
   workup.ADDITIONthe reaction mixture was poured onto ice
3. 3
   Другоеthe reaction
4. 4
   Экстракцияextracted with ethyl acetate
5. 5
   ПромывкаThe organic layer was washed with a saturated aqueous solution of sodium chloride
6. 6
   Сушкаdried over anhydrous magnesium sulfate
7. 7
   Концентрированиеconcentrated under reduced pressure

Методика

4-Methoxy-2-nitro-1-phenylbenzene (1.86 g, 8.31 mmol) was dissolved in dichloromethane (40 mL) and thereto was added, under ice-water cooling, a solution of boron tribromide (2 mL) in dichloromethane (10 mL) After stirring at room temperature for 18 hours, the reaction mixture was poured onto ice to stop the reaction and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to obtain 3-nitro-4-phenylphenol as a crude material.

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