Реакция #1605805

Уравнение реакции

4-(3-Amino-4-phenylphenyl)butyric acid

tosylic acid hydrate

water

→

benzyl 4-(3-amino-4-phenylphenyl)butyrate tosylate

Выход 171.2%

Растворители

toluene

benzyl alcohol

Условия реакции

Обработка

1. 1
   workup.ADDITIONwere added
2. 2
   Температураthe mixture was heated
3. 3
   Другоеremoved by a Dean-Stark trap
4. 4
   КонцентрированиеThe reaction solution was concentrated under reduced pressure
5. 5
   Другоеa solid obtained
6. 6
   Промывкаwas washed with a mixed solvent of hexane-ethyl acetate (4:1)
7. 7
   ФильтрацияThe solid was collected by filtration
8. 8
   Другоеdried under reduced pressure

Методика

To a suspension of 4-(3-Amino-4-phenylphenyl)butyric acid (21.6 g, 84.6 mmol) in toluene (300 mL), benzyl alcohol (50 mL) and tosylic acid hydrate (17.7 g, 93.0 mmol) were added, and the mixture was heated under reflux for 5 hours with water removed by a Dean-Stark trap. The reaction solution was concentrated under reduced pressure and a solid obtained was washed with a mixed solvent of hexane-ethyl acetate (4:1). The solid was collected by filtration and dried under reduced pressure to obtain benzyl 4-(3-amino-4-phenylphenyl)butyrate tosylate (41.2 g).

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