Реакция #1605795

Уравнение реакции

5-Acetyl-8-hydroxy-1H-quinolin-2-one

potassium carbonate

benzyl bromide

→

5-acetyl-8-benzyloxy-1H-quinolin-2-one

Выход 87.4%

Растворители

N,N-dimethylformamide

Условия реакции

Обработка

1. 1
   ДругоеThe insoluble matter was removed by filtration
2. 2
   Промывкаwashed with N,N-dimethylformamide
3. 3
   workup.ADDITIONThe filtrate and the washing were mixed
4. 4
   Концентрированиеconcentrated under reduced pressure
5. 5
   workup.ADDITIONTo the residue was added
6. 6
   Другоеpurified water (3.3 L)
7. 7
   workup.STIRRINGthe mixture was stirred at room temperature overnight
8. 8
   ФильтрацияThe precipitate was collected by filtration
9. 9
   Промывкаwashed with purified water
10. 10
    Другоеdried under vacuum

Методика

5-Acetyl-8-hydroxy-1H-quinolin-2-one (430 g, 2.12 mol) was suspended in N,N-dimethylformamide (3.3 L), potassium carbonate (298 g, 2.16 mol) and subsequently benzyl bromide (298 g, 2.11 mol) were added thereto, and the mixture was stirred at room temperature for 2 hours. The insoluble matter was removed by filtration and washed with N,N-dimethylformamide. The filtrate and the washing were mixed and concentrated under reduced pressure. To the residue was added purified water (3.3 L) and the mixture was stirred at room temperature overnight. The precipitate was collected by filtration, washed with purified water, and dried under vacuum to obtain 5-acetyl-8-benzyloxy-1H-quinolin-2-one (541 g).

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