Реакция #1605772

Уравнение реакции

NH3

2-methoxy-4-methylbenzoic acid

EDC

HOBt

→

2-methoxy-4-methylbenzamide

Выход 83.0%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   Промывкаthen washed successively with HCl (1N)
2. 2
   СушкаNaHCO3, water and brine, dried over MgSO4
3. 3
   Фильтрацияfiltered
4. 4
   Другоеevaporated
5. 5
   ДругоеThe residue was recrystallized from ethyl acetate/hexane

Методика

To a mixture of 2-methoxy-4-methylbenzoic acid (20 g, 120.4 mmol), EDC (23.1 g, 120.4 mmol) and HOBt (16.3 g, 120.4 mmol) in dichloromethane (1 L) was added NH3 (7N in MeOH, 52 mL, 3 eq) dropwise. The reaction mixture was stirred at room temperature overnight then washed successively with HCl (1N), saturated aq.NaHCO3, water and brine, dried over MgSO4, filtered and evaporated. The residue was recrystallized from ethyl acetate/hexane to give 16.5 gr of 2-methoxy-4-methylbenzamide (83% yield).

Источник