Реакция #1605751

Уравнение реакции

2-methylheptan-4-one

ammonium acetate

sodium cyanoborohydride

→

2-methylheptan-4-amine

Выход 77.2%

Растворители

methanol

Условия реакции

Обработка

1. 1
   ДругоеThe solvent was removed under reduced pressure
2. 2
   workup.ADDITIONthe residue was diluted with water and basified with 15% NaOH aqueous
3. 3
   Экстракцияextracted with ether
4. 4
   ПромывкаThe extract was washed with brine
5. 5
   Сушкаdried over anhydrous magnesium sulfate
6. 6
   Фильтрацияfiltered
7. 7
   Другоеevaporated

Методика

To a solution of 2-methylheptan-4-one (4.24 g, 33.07 mmol), in methanol (60 mL), were added ammonium acetate (25.50 g, 330.71 mmol) and sodium cyanoborohydride (2.08 g, 33.07 mmol). The reaction mixture was stirred at room temperature for about 24 hours. The solvent was removed under reduced pressure and the residue was diluted with water and basified with 15% NaOH aqueous and extracted with ether. The extract was washed with brine, dried over anhydrous magnesium sulfate, filtered and evaporated to give 3.3 g of 2-methylheptan-4-amine (77%). MS (M+H, 130).

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