Реакция #160012

ord-e9bdc129581e4f1189be83baf8ed3d7a

Уравнение реакции

CN(C)c1cc(F)c2c(c1)Sc1cc(N3CCOCC3)ccc1N2C(=O)OC(C)(C)C
3-dimethylamino-7-morpholino-1-fluoro-10-Boc-phenothiazine
ClCCl
dichloromethane
→
CN(C)c1cc(F)c2nc3ccc(N4CCOCC4)cc3[s+]c2c1.[Cl-]
3-Dimethylamino-7-morpholino-1-fluorophenothiazin-5-ium chloride

Реактанты

CN(C)c1cc(F)c2c(c1)Sc1cc(N3CCOCC3)ccc1N2C(=O)OC(C)(C)C
3-dimethylamino-7-morpholino-1-fluoro-10-Boc-phenothiazine
ClCCl
dichloromethane

Реагенты

Нет

Условия реакции

Температура
40°CELSIUS
Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    ДругоеSolvent was removed under vacuum
  2. 2
    ДругоеProduct was purified by flash chromatography

Методика

To a solution 3-dimethylamino-7-morpholino-1-fluoro-10-Boc-phenothiazine (15) (100 mg) in dichloromethane (10 mL) HCl (1 mL, 4 M solution in 1,4-dioxane)) was added. The reaction mixture was stirred at 40° C. for 3 h. Solvent was removed under vacuum. Product was purified by flash chromatography.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US08828986B2uspto-grants-2014_09