Реакция #1598

Уравнение реакции

4-benzoylbutyric acid

hydrazine

water

→

desired product

Выход 39.0%

7-phenyl-1,2-diazapin-3-one

Выход 39.0%

Растворители

toluene

toluene

Et2O

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added in one portion
2. 2
   Температураthe reaction was heated
3. 3
   ТемператураThe reaction mixture was cooled
4. 4
   Промывкаwashed with H2O (100 ml) and brine (100 ml)
5. 5
   ЭкстракцияThe ether extract
6. 6
   Сушкаwas dried over anhydrous MgSO4
7. 7
   Фильтрацияfiltered
8. 8
   Другоеto yield an orange semisolid which
9. 9
   Другоеwas triturated with ether

Методика

To a mixture of 10 g (0.052 mole) of 4-benzoylbutyric acid in 300 ml of toluene, hydrazine was added in one portion and the reaction was heated to reflux until all water had ceased to azeotrope. The reaction mixture was cooled and the toluene was stripped off in vacuo. The residue was dissolved in 200 ml Et2O and washed with H2O (100 ml) and brine (100 ml). The ether extract was dried over anhydrous MgSO4, filtered and stripped to yield an orange semisolid which was triturated with ether to yield 3.8 g (39%) of the desired product as a yellow solid.

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