Реакция #1597319

Уравнение реакции

diethyl zinc

methyl 3-(vinyloxy)benzoate

iodochloromethane

→

desired product

methyl 3-(cyclopropyloxy)benzoate

Растворители

dichloroethane

Условия реакции

Обработка

1. 1
   ДругоеThe cooling bath was removed
2. 2
   ДругоеThe reaction mixture was quenched with 1N HCl
3. 3
   Экстракцияextracted with methylene chloride (three times)
4. 4
   Сушкаdried with MgSO4
5. 5
   Концентрированиеconcentrate under vacuum

Методика

To a solution of methyl 3-(vinyloxy)benzoate (0.83 g, 3.99 mmol) in dichloroethane (20 mL) was added iodochloromethane (1.09 mL, 14.9 mmol). The solution was cooled to 0° C. and diethyl zinc (1.0 M in hexanes, 7.48 mL, 7.48 mmol) was added. The cooling bath was removed and the reaction was stirred at rt for 30 min. The reaction mixture was quenched with 1N HCl, extracted with methylene chloride (three times), dried with MgSO4 and concentrate under vacuum to afford the desired product.

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