Реакция #159731

Уравнение реакции

4-(1-(5-chloro-2-(3-(3-fluorobenzoyl)azetidin-1-yl)nicotinamido)cyclopropyl)benzoic acid

O-methylhydroxylamine hydrochloride

→

title compound ( E26 )

Выход 22.9%

4-(1-(5-chloro-2-(3-((3-fluorophenyl)(methoxyimino)methyl)azetidin-1-yl)nicotinamido)cyclopropyl) benzoic acid

Выход 22.9%

Растворители

pyridine

Условия реакции

Обработка

1. 1
   ДругоеSolvents were evaporated in vacuo
2. 2
   workup.ADDITIONthe residue was diluted with water (5 ml)
3. 3
   Экстракцияextracted with ethylacetate (3×20 ml)
4. 4
   ДругоеCollected organics, after solvent evaporation
5. 5
   Другоеafforded a residue that
6. 6
   Промывкаwas washed with methanol
7. 7
   Другоеdried in vacuo

Методика

4-(1-(5-chloro-2-(3-(3-fluorobenzoyl)azetidin-1-yl)nicotinamido)cyclopropyl)benzoic acid (E25) (12.6 mg, 0.025 mmol) was dissolved in dry pyridine (1.2 ml) then O-methylhydroxylamine hydrochloride (4.3 mg, 0.051 mmol) was added and the resulting mixture was stirred at room temperature for 60 h. Solvents were evaporated in vacuo, and the residue was diluted with water (5 ml) and extracted with ethylacetate (3×20 ml). Collected organics, after solvent evaporation, afforded a residue that was washed with methanol and dried in vacuo to afford the title compound (E26) (D021/092/2) (3 mg).

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