Реакция #1596945

Уравнение реакции

2-(4-benzyloxy-3-fluorophenyl)-4-bromo-5-propyltetrahydropyran

triethylamine

→

2-fluoro-4-(5-propyltetrahydropyran-2-yl)phenol

Растворители

MTBE

toluene water

Условия реакции

Обработка

1. 1
   Другоеthe organic phase is separated off
2. 2
   ЭкстракцияThe aqueous phase is extracted with MTBE
3. 3
   ПромывкаThe combined organic phases are washed with water
4. 4
   Другоеdried
5. 5
   КонцентрированиеThe solution is concentrated to dryness
6. 6
   Другоеthe residue is used directly for the following reaction

Методика

123.0 g (0.30 mol) of 2-(4-benzyloxy-3-fluorophenyl)-4-bromo-5-propyltetrahydropyran are hydrogenated in toluene/water in the presence of Pd/C (5% of Pd) and 86.0 ml (0.60 mol) of triethylamine. The reaction solution is diluted with MTBE, and the organic phase is separated off. The aqueous phase is extracted with MTBE. The combined organic phases are washed with water and dried using sodium sulfate. The solution is concentrated to dryness, and the residue is used directly for the following reaction.

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