Реакция #1596940

Уравнение реакции

phenyl isothiocyanate

2-amino-2-methyl-1-propanol

→

N-(1-hydroxy-2-methylpropan-2-yl)-N′-phenylthiourea

Выход 60.0%

Растворители

chloroform

chloroform

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas slowly added dropwise to the mixture over one hour
2. 2
   workup.ADDITIONUpon completion of the addition
3. 3
   workup.STIRRINGthe resulting mixture was stirred for 12 hours at room temperature
4. 4
   ТемператураThe precipitated crystals were refluxed
5. 5
   Температураwith heat
6. 6
   workup.DISSOLUTIONto be dissolved
7. 7
   Другоеrecrystallized
8. 8
   ДругоеThe crystals thus obtained
9. 9
   Фильтрацияwere collected by filtration
10. 10
    Промывкаwashed with 20 mL of diethyl ether three times
11. 11
    Другоеdried under reduced pressure at room temperature

Методика

In 500 g of chloroform was dissolved 2-amino-2-methyl-1-propanol (61.6 g, 0.69 moL). Then, 300 g of chloroform solution containing phenyl isothiocyanate (81.6 g, 0.6 moL) was slowly added dropwise to the mixture over one hour, while stirring. Upon completion of the addition, the resulting mixture was stirred for 12 hours at room temperature. The precipitated crystals were refluxed with heat to be dissolved and then recrystallized. The crystals thus obtained were collected by filtration, washed with 20 mL of diethyl ether three times, and then dried under reduced pressure at room temperature to give 80.1 g of N-(1-hydroxy-2-methylpropan-2-yl)-N′-phenylthiourea (yield 60%).

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