Реакция #159487

Уравнение реакции

Pivaloyl chloride

3-(3,5-dimethylbiphen-4-yl)bicyclo[3.2.1]octane-2,4-dione

triethylamine

→

3-(3,5-dimethylbiphen-4-yl)-4-oxo-bicyclo[3.2.1]oct-2-en-2-yl 2,2-dimethylpropionate

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   ДругоеThe reaction mixture is evaporated under reduced pressure
2. 2
   Другоеthe residue is purified by column chromatography on silica gel

Методика

Pivaloyl chloride (248 μl, 2 mmol) is added to a solution of 3-(3,5-dimethylbiphen-4-yl)bicyclo[3.2.1]octane-2,4-dione (148 mg, 0.46 mmol) in dichloromethane (10 ml) and triethylamine (280 μl, 2 mmol) at room temperature. The reaction mixture is stirred at room temperature overnight. The reaction mixture is evaporated under reduced pressure and the residue is purified by column chromatography on silica gel to afford 3-(3,5-dimethylbiphen-4-yl)-4-oxo-bicyclo[3.2.1]oct-2-en-2-yl 2,2-dimethylpropionate.

Источник