Реакция #159220

Уравнение реакции

6-(2-methoxycarbonylamino-3-methyl-butyryl)-5-oxa-6-aza-spiro[3.4]octane-7-carboxylic acid ethyl ester

lithium hydroxide

→

6-(2-methoxycarbonylamino-3-methyl-butyryl)-5-oxa-6-aza-spiro[3.4]octane-7-carboxylic acid

Растворители

ethanol

Условия реакции

Обработка

1. 1
   КонцентрированиеThe reaction was partially concentrated
2. 2
   Промывкаthe resulting aqueous solution was washed with ethyl acetate
3. 3
   ЭкстракцияThe acidic aqueous layer was extracted twice with ethyl acetate
4. 4
   ПромывкаThe combined organic layers were washed with brine
5. 5
   Сушкаdried (MgSO4)
6. 6
   Концентрированиеconcentrated

Методика

To a solution of 6-(2-methoxycarbonylamino-3-methyl-butyryl)-5-oxa-6-aza-spiro[3.4]octane-7-carboxylic acid ethyl ester (1.31 g, 3.83 mmol) in ethanol (10 mL) was added a solution of lithium hydroxide (1M in water, 7.6 mL, 7.6 mmol). The reaction was stirred at room temperature for 30 minutes. The reaction was partially concentrated and the resulting aqueous solution was washed with ethyl acetate. The ethyl acetate layer was discarded and the aqueous layer was acidified using concentrated HCl. The acidic aqueous layer was extracted twice with ethyl acetate. The combined organic layers were washed with brine, dried (MgSO4) and concentrated to yield crude 6-(2-methoxycarbonylamino-3-methyl-butyryl)-5-oxa-6-aza-spiro[3.4]octane-7-carboxylic acid, which was used without further purification.

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