Реакция #159096

Уравнение реакции

3-Bromo-6H-benzo[c]chromene-8-carboxylic acid methyl ester

sodium hydroxide

HCl

→

3-Bromo-6H-benzo[c]chromene-8-carboxylic acid

Растворители

THF MeOH

Условия реакции

Обработка

1. 1
   ДругоеThe solvents were removed under reduced pressure
2. 2
   workup.ADDITIONThe mixture was diluted with acetonitrile and water
3. 3
   Другоеwas freezer-dried

Методика

The solution of 3-Bromo-6H-benzo[c]chromene-8-carboxylic acid methyl ester (160 mg, 0.5 mmol) and sodium hydroxide (1.0 N, 1 ml, 1 mmol) in THF/MeOH (2 ml/2 ml) was heated at 50° C. for 3 hours. The mixture was cooled to 25° C. and was acidified with 2 N HCl (0.6 ml). The solvents were removed under reduced pressure. The mixture was diluted with acetonitrile and water, and was freezer-dried to give 3-Bromo-6H-benzo[c]chromene-8-carboxylic acid as brown powder.

Источник