Реакция #158434

Уравнение реакции

HCl

methyl 4-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)butanoate

sodium hydroxide

→

residue

Выход 97.8%

4-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)butanoic acid

Выход 97.8%

Растворители

MeOH

Условия реакции

Обработка

1. 1
   Экстракцияthe product was extracted with EtOAc (2×)
2. 2
   ПромывкаThe combined extracts were washed with brine
3. 3
   Сушкаdried over Na2SO4
4. 4
   Другоеevaporated

Методика

To a solution of methyl 4-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)butanoate (0.137 g, 0.43 mmol) in MeOH (3 mL) was added 1N sodium hydroxide (1.290 mL, 1.290 mmol), and the mixture was stirred at room temp for 4 hrs. It was made acidic with 1.4 mL of 1N HCl and the product was extracted with EtOAc (2×). The combined extracts were washed with brine, dried over Na2SO4 and evaporated to give a solid residue (128 mg).

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