Реакция #1583825

Уравнение реакции

methyl 2-(5-bromo-2-chlorophenyl)hydrazine carboxylate

product

methyl 2-(5-bromo-2-chlorophenyl)hydrazine carboxylate

[3-(trifluoromethoxy)phenyl]boronic acid

cesium carbonate

triphenylphosphine

→

title compound

methyl 2-[4-chloro-3′-(trifluoromethoxy)[1,1′-biphenyl]-3-yl]hydrazine carboxylate

Растворители

diethyl ether

toluene

methanol

Условия реакции

Обработка

1. 1
   Температураwas heated
2. 2
   Температураat refluxed for 24 h
3. 3
   ТемператураAfter cooling
4. 4
   Промывкаwashed with water
5. 5
   СушкаAfter drying over sodium sulfate
6. 6
   Другоеthe solvent was removed under reduced pressure
7. 7
   ДругоеThe residue was purified by flash chromatography
8. 8
   Другоеto afford a solid matieral (1.3 g), which
9. 9
   workup.ADDITIONa mixture of starting material

Методика

A mixture of methyl 2-(5-bromo-2-chlorophenyl)hydrazine carboxylate (i.e. the product of Step B) (1.27 g, 4.5 mmol), [3-(trifluoromethoxy)phenyl]boronic acid (1.85 g, 9 mmol), cesium carbonate (2.9 g, 9 mmol), tris(dibenzylideneacetone)dipalladium (0.18 g, 0.2 mmol) and triphenylphosphine (1.2 g, 4.5 mmol) in toluene (60 mL) and methanol (60 mL) was heated at refluxed for 24 h. After cooling, the reaction mixture was taken up in diethyl ether and washed with water. After drying over sodium sulfate, the solvent was removed under reduced pressure. The residue was purified by flash chromatography using 25% ethyl acetate in hexanes as eluant to afford a solid matieral (1.3 g), which was a mixture of starting material and the title compound.

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