Реакция #158271

Уравнение реакции

3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)benzoic acid

hydrazine monohydrate

→

title compound

3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)benzohydrazide

Растворители

THF

Условия реакции

Обработка

1. 1
   workup.STIRRINGthe mixture was stirred at room temperature for 16 hr
2. 2
   ДругоеThe solvent in the reaction mixture was evaporated under reduced pressure, and water
3. 3
   workup.ADDITIONwas added to the residue
4. 4
   ФильтрацияThe resultant solid was collected by filtration
5. 5
   Промывкаwashed with water
6. 6
   Другоеdried under reduced pressure
7. 7
   Промывкаwashed with IPE

Методика

N,N′-Carbonyldiimidazole (115 g) was added to a suspension of 3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)benzoic acid (83.0 g) in THF (1 L) at room temperature, and the mixture was stirred for 1 hr. The reaction mixture was cooled to −10° C., hydrazine monohydrate (173 mL) was added, and the mixture was stirred at room temperature for 16 hr. The solvent in the reaction mixture was evaporated under reduced pressure, and water was added to the residue. The resultant solid was collected by filtration, washed with water, dried under reduced pressure, and washed with IPE to give the title compound (85.8 g).

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