Реакция #157995

Уравнение реакции

2-Cyano-N-[2-ethyl-6-methyl-4-(1,1,1,2,3,3,4,4,4-nonafluorobutan-2-yl)phenyl]quinoline-6-carboxamide

urea hydrogen peroxide

trifluoroacetic anhydride

→

2-cyano-N-[2-ethyl-6-methyl-4-(1,1,1,2,3,3,4,4,4-nonafluorobutan-2-yl)phenyl]quinoline-6-carboxamide-1-oxide

Выход 81.0%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   КонцентрированиеThe reaction solution was concentrated under the reduced pressure
2. 2
   workup.DISSOLUTIONthe resulting residues were dissolved in ethyl acetate
3. 3
   ПромывкаThe solution was washed with water
4. 4
   Сушкаdried over anhydrous magnesium sulfate
5. 5
   ФильтрацияThe drying agent was filtered off
6. 6
   Другоеthe solvent was removed by distillation under the reduced pressure
7. 7
   ДругоеThe resulting residues were purified by column chromatography

Методика

2-Cyano-N-[2-ethyl-6-methyl-4-(1,1,1,2,3,3,4,4,4-nonafluorobutan-2-yl)phenyl]quinoline-6-carboxamide (240 mg) was dissolved in dichloromethane, added with urea-hydrogen peroxide adduct (85 mg) and trifluoroacetic anhydride (190 mg), and stirred at room temperature for 20 hours. The reaction solution was concentrated under the reduced pressure, and the resulting residues were dissolved in ethyl acetate. The solution was washed with water and dried over anhydrous magnesium sulfate. The drying agent was filtered off and the solvent was removed by distillation under the reduced pressure. The resulting residues were purified by column chromatography to obtain 2-cyano-N-[2-ethyl-6-methyl-4-(1,1,1,2,3,3,4,4,4-nonafluorobutan-2-yl)phenyl]quinoline-6-carboxamide-1-oxide (0.20 g, 81%).

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