Реакция #1578

Уравнение реакции

sodium hydroxide

4'-chloro-2'-fluoro-5'-[hexahydro-2,4,6-trioxo-3-(2-propynyl)-s-triazin-1-yl]acetanilide

hydrochloric acid

ethyl acetate

→

title product

Выход 82.2%

1-(5-Amino-2-chloro-4-fluorophenyl)-3-(2-propynyl)-s-triazine-2,4,6-(1H, 3H, 5H)-trione

Выход 82.2%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   Температураis refluxed for 3 hours
2. 2
   Другоеthe phases are separated
3. 3
   ПромывкаThe organic phase is washed sequentially with saturated sodium hydrogen carbonate solution and brine
4. 4
   Концентрированиеconcentrated in vacuo

Методика

A mixture of 4'-chloro-2'-fluoro-5'-[hexahydro-2,4,6-trioxo-3-(2-propynyl)-s-triazin-1-yl]acetanilide (3.00 g, 8.5 mmol), and 3N hydrochloric acid (25 mL) in ethanol (50 mL) is refluxed for 3 hours, cooled to room temperature, and poured into ethyl acetate. 3N sodium hydroxide solution (25 mL) is added to the organic solution, and the phases are separated. The organic phase is washed sequentially with saturated sodium hydrogen carbonate solution and brine, and concentrated in vacuo to give the title product as a beige solid (2.17 g, mp 118°-121° C.).

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