Реакция #157649

Уравнение реакции

({2-[(1-benzofuran-2-ylsulfonyl)amino]-4-chlorophenyl}sulfanyl)acetic acid

mCPBA

→

title compound

Выход 74.7%

({2-[(1-benzofuran-2-ylsulfonyl)amino]-4-chlorophenyl}sulfinyl)acetic acid

Выход 74.7%

Растворители

CH2Cl2

acetonitrile

Условия реакции

Обработка

1. 1
   Концентрированиеwas concentrated
2. 2
   ДругоеThe residue was purified by flash column chromatography on silica gel (50-100% EtOAc in hexane

Методика

To a solution of ({2-[(1-benzofuran-2-ylsulfonyl)amino]-4-chlorophenyl}sulfanyl)acetic acid (44 mg, 0.11 mmol) in CH2Cl2 (2 ml) and acetonitrile (2 ml) was added mCPBA (27 mg, ˜0.11 mmol). The reaction was stirred at room temperature for 4 hours and was concentrated. The residue was purified by flash column chromatography on silica gel (50-100% EtOAc in hexane, then 20-30% MeOH in EtOAc) followed by PTLC (25% MeOH in EtOAc) to yield the title compound (34 mg, 74%).

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