Реакция #1569

Уравнение реакции

2-aminoethanethiol

triethylamine

ethyl 2,3-di-bromopropionate

chloroform toluene

→

title product

Ethyl 3-thiomorpholinecarboxylate

Растворители

chloroform

Условия реакции

Обработка

1. 1
   Фильтрацияfiltered
2. 2
   Концентрированиеconcentrated in vacuo
3. 3
   Другоеto obtain an orange liquid
4. 4
   workup.DISTILLATIONdistilled

Методика

A warm solution of 2-aminoethanethiol (10.0 g, 0.130 mol) and triethylamine (36 mL, 0.260 mol) in chloroform is added over 5 minutes to a solution of ethyl 2,3-di-bromopropionate (33.9 g, 0.130 mol) in a chloroform/toluene (1:1.6) solution. The reaction mixture is stirred at room temperature for 2.5 hours, filtered and concentrated in vacuo to obtain an orange liquid. The liquid is vacuum distilled to give the title product as a colorless liquid, bp 121°-124° C. at 3 mm Hg.

Источник