Реакция #156699

Уравнение реакции

2-(4-[1,4]Diazepan-1-yl-3-methoxy-phenyl)-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-2H-isoquinolin-1-one

1-Bromo-3-fluoro-propane

cesium carbonate

→

4-(2-Methoxy-4-{1-oxo-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-1H-isoquinolin-2-yl}-phenyl)-[1,4]diazepane-1-carboxylic acid 3-fluoro-propyl ester

Растворители

DMF

Условия реакции

Обработка

1. 1
   ДругоеThe crude mixture was purified by preparative HPLC
2. 2
   ДругоеThe product with the molecular weight of 553.64 (C30H36FN3O6) was obtained in this way

Методика

To a solution of 2-(4-[1,4]Diazepan-1-yl-3-methoxy-phenyl)-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-2H-isoquinolin-1-one (50 mg) and 1-Bromo-3-fluoro-propane (18 mg) in DMF (1 mL) was added cesium carbonate (54 mg) and the mixture was stirred overnight. The crude mixture was purified by preparative HPLC. The product with the molecular weight of 553.64 (C30H36FN3O6) was obtained in this way; MS (ESI): 554 (M+H+).

Источник