Реакция #156592

ord-d2c5c17b53004ccd883e72f32cd67d1d

Уравнение реакции

CCCCOc1ccc2c(c1)CCN(c1ccc(N3CC[C@@H](NC)C3)c(F)c1)C2=O
6-Butoxy-2-[3-fluoro-4-((R)-3-methylaminopyrrolidin-1-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one
C=CS(C)(=O)=O
methanesulfonylethene
→
CCCCOc1ccc2c(c1)CCN(c1ccc(N3CC[C@@H](N(C)CCS(C)(=O)=O)C3)c(F)c1)C2=O
6-Butoxy-2-(3-fluoro-4-{(R)-3-[(2-methanesulfonylethyl)methylamino]pyrrolidin-1-yl}phenyl)-3,4-dihydro-2H-isoquinolin-1-one

Реактанты

CCCCOc1ccc2c(c1)CCN(c1ccc(N3CC[C@@H](NC)C3)c(F)c1)C2=O
6-Butoxy-2-[3-fluoro-4-((R)-3-methylaminopyrrolidin-1-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one
C=CS(C)(=O)=O
methanesulfonylethene

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    ДругоеThe product with the molecular weight of 517.67 (C27H36FN3O4S) was obtained in this way

Методика

6-Butoxy-2-[3-fluoro-4-((R)-3-methylaminopyrrolidin-1-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one was reacted with methanesulfonylethene by method G. The product with the molecular weight of 517.67 (C27H36FN3O4S) was obtained in this way; MS (ESI): 518 (M+H+).

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US08822495B2uspto-grants-2014_09