Реакция #156546

Уравнение реакции

(R)-2-(4-chloro-2-methoxypyridin-3-yl)-6-(2,3-dihydroxypropyl)imidazo[4,5-f]isoindole-5,7(1H,6H)-dione

HCl

→

(R)-2-(4-chloro-2-oxo-1,2-dihydropyridin-3-yl)-6-(2,3-dihydroxypropyl)imidazo[4,5-f]isoindole-5,7(1H,6H)-dione

Растворители

dioxane

Условия реакции

Обработка

1. 1
   ТемператураThe mixture was heated
2. 2
   Температураto reflux
3. 3
   Температураmaintained for 3 h
4. 4
   ДругоеThe solvent was removed by rotary evaporation
5. 5
   Другоеthe solid residue was triturated with n-butanol three times
6. 6
   Другоеto give a white solid which

Методика

To a solution of (R)-2-(4-chloro-2-methoxypyridin-3-yl)-6-(2,3-dihydroxypropyl)imidazo[4,5-f]isoindole-5,7(1H,6H)-dione (380 mg, 0.95 mmol) in 50 mL of dioxane was added 1 mL of conc. HCl. The mixture was heated to reflux and maintained for 3 h. The solvent was removed by rotary evaporation and the solid residue was triturated with n-butanol three times to give a white solid which was used directly in the next step. APCI MS: m/z 389.0 (M+1).

Источник