Реакция #1563935

Уравнение реакции

tert-butyl (3-fluoropyridin-4-yl)carbamate

O-(2,4-dinitrophenyl)hydroxylamine

→

1-amino-4-((tert-butoxycarbonyl)amino)-3-fluoropyridin-1-ium 2,4-dinitrophenolate

Растворители

MeCN

MeCN

Условия реакции

Обработка

1. 1
   Другоеreaction mass
2. 2
   Другоеreaction mass
3. 3
   Концентрированиеwas concentrated at temperature below 40° C. under reduced pressure
4. 4
   Другоеto afford Int-11 (50 g) which
5. 5
   Другоеwas used in the next step without further purification

Методика

A solution of tert-butyl (3-fluoropyridin-4-yl)carbamate (25.0 g, 125 mmol) in MeCN (200 ml), was added O-(2,4-dinitrophenyl)hydroxylamine (26.64 g, 125 mmol) in MeCN (200 ml), drop wise over 30 min at RT, reaction mass was stirred at 40° C. for 12 hrs, reaction mass was concentrated at temperature below 40° C. under reduced pressure to afford Int-11 (50 g) which was used in the next step without further purification.

Источник