Реакция #1563934

Уравнение реакции

NaBH4

5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole

→

title compound

Выход 79.8%

2-(2,5-difluorophenyl)pyrrolidine

Выход 79.8%

Растворители

MeOH H2O

Условия реакции

Обработка

1. 1
   ДругоеThe reaction mixture was quenched with 1N aqueous HCl solution
2. 2
   Экстракцияextracted with DCM
3. 3
   Сушкаdried over anhydrous sodium sulphate
4. 4
   Концентрированиеconcentrated under reduced pressure

Методика

NaBH4 (12 g, 314.9 mmol) was added to a solution of 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole (28.5 g, 157.4 mmol) in a mixture of MeOH:H2O (4:1, 250 mL) and stirring was continued at 25-35° C. for 2 h. The reaction mixture was quenched with 1N aqueous HCl solution and basified with 2N aqueous NaOH solution, extracted with DCM, dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford 23 g of the title compound.

Источник