Реакция #1563907

Уравнение реакции

NaHCO3

3,4-(Methylenedioxy)aniline

Ac2O

→

N-(benzo[d][1,3]dioxol-5-yl)acetamide

Выход 95.0%

Растворители

AcOH

Условия реакции

Обработка

1. 1
   ДругоеAfter reaction
2. 2
   Фильтрацияfiltered
3. 3
   ЭкстракцияThe filtrate was extracted with ethyl acetate

Методика

To a solution of 3,4-(Methylenedioxy)aniline (8 g, 58.3 mmol) in AcOH (120 ml) was added Ac2O (48 mL). The mixture was stirred for overnight. After reaction, the mixture was poured into saturated NaHCO3 solution, and then filtered. The filtrate was extracted with ethyl acetate to give N-(benzo[d][1,3]dioxol-5-yl)acetamide (10 g, 95%). LCMS: 180[M+1]+; 1H NMR (DMSO-d6) δ 2.0 (s, 3H), 5.96 (s, 2H), 6.82 (d, 1H, J=8.1 Hz), 6.91 (d, 1H, J=2.1 Hz), 7.30 (d, 1H, J=1.8 Hz), 9.84 (s, 1H).

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