Реакция #1563902

Уравнение реакции

(6-Iodobenzo[d][1,3]dioxol-5-yl)methanol

PCC

→

6-iodobenzo[d][1,3]dioxole-5-carbaldehyde

Выход 77.0%

Растворители

CH2Cl2

CH2Cl2

Условия реакции

Обработка

1. 1
   ДругоеAfter reaction
2. 2
   Другоеthe crude product was purified by column chromatography on silica gel (petroleum ether)

Методика

(6-Iodobenzo[d][1,3]dioxol-5-yl)methanol (2.7 g, 9.7 mmol) in dry CH2Cl2 was added dropwise to PCC (3.1 g, 14.6 mmol) in dry CH2Cl2 at 0° C. under N2 atmosphere. The mixture was stirred at room temperature for 20 h. After reaction, the crude product was purified by column chromatography on silica gel (petroleum ether) to obtain 6-iodobenzo[d][1,3]dioxole-5-carbaldehyde (2 g, 77%) as white solid. LCMS: 277[M+1]+; 1H NMR (DMSO-d6) δ 6.20 (s, 2H), 7.28 (s, 1H), 7.61 (s, 1H), 9.79 (s, 1H).

Источник