Реакция #156196

Уравнение реакции

hydrogen chloride ethanol

ethanol

1-Methyl-6-{2-[(2-pyridin-3-ylethyl)pyridin-3-ylmethylamino]ethoxy}-1H-quinolin-2-one

→

title compound

1-methyl-6-{2-[(2-pyridin-3-ylethyl)pyridin-3-ylmethylamino]ethoxy}-1H-quinolin-2-one trihydrochloride

Растворители

ethyl acetate

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added to the residue
2. 2
   ДругоеThe precipitated insoluble matter was separated
3. 3
   Промывкаwashed with ethyl acetate
4. 4
   Другоеdried

Методика

A 1N-hydrogen chloride ethanol solution (1.7 ml) was added to an ethanol solution (10 ml) of 1-Methyl-6-{2-[(2-pyridin-3-ylethyl)pyridin-3-ylmethylamino]ethoxy}-1H-quinolin-2-one (195 mg), which was stirred at room temperature. The reaction mixture was condensed under reduced pressure and ethyl acetate was added to the residue. The precipitated insoluble matter was separated, washed with ethyl acetate, and dried to give the title compound (199 mg) as a pale yellow powder.

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