Реакция #156133

Уравнение реакции

1-ethyl-3,3,5-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-7-carbaldehyde

2-methyl-2-butene

sodium dihydrogenphosphate

sodium chlorite

→

title compound

Выход 44.0%

1-Ethyl-3,3,5-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-7-carboxylic acid

Выход 44.0%

Растворители

H2O

t-butanol

Water

Условия реакции

Обработка

1. 1
   Экстракцияfollowed by extraction
2. 2
   СушкаThe organic layer was dried with sodium sulfate
3. 3
   Другоеcondensed under reduced pressure

Методика

To a t-butanol (20 ml) and H2O (5 ml) solution of 1-ethyl-3,3,5-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-7-carbaldehyde (2.25 g) and 2-methyl-2-butene (3.25 ml) were added sodium dihydrogenphosphate (0.92 g) and sodium chlorite (2.081 g), and the mixture was stirred at room temperature overnight. Water was added to the reaction mixture, followed by extraction using ethyl acetate. The organic layer was dried with sodium sulfate, and was condensed under reduced pressure to give the title compound (0.98 g) as a white powder.

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