Реакция #156030

ord-d940fddcb6a94b3e9d31c9ecd2691295

Уравнение реакции

N=C(NO)N1CCC(N(C(=O)c2ccc(-c3cnco3)cc2)C2CC2)CC1
N-cyclopropyl-N-[1-(N-hydroxycarbamimidoyl)-piperidin-4-yl]-4-oxazol-5-yl-benzamide
O=C(Cl)C1CCC1
cyclobutanecarbonyl chloride
→
O=C(c1ccc(-c2cnco2)cc1)N(C1CC1)C1CCN(c2noc(C3CCC3)n2)CC1
title compound
O=C(c1ccc(-c2cnco2)cc1)N(C1CC1)C1CCN(c2noc(C3CCC3)n2)CC1
N-[1-(5-Cyclobutyl-[1,2,4]oxadiazol-3-yl)-piperidin-4-yl]-N-cyclopropyl-4-oxazol-5-yl-benzamide

Реактанты

N=C(NO)N1CCC(N(C(=O)c2ccc(-c3cnco3)cc2)C2CC2)CC1
N-cyclopropyl-N-[1-(N-hydroxycarbamimidoyl)-piperidin-4-yl]-4-oxazol-5-yl-benzamide
O=C(Cl)C1CCC1
cyclobutanecarbonyl chloride

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

The title compound is prepared from N-cyclopropyl-N-[1-(N-hydroxycarbamimidoyl)-piperidin-4-yl]-4-oxazol-5-yl-benzamide and cyclobutanecarbonyl chloride following a procedure analogous to that described in Example 47. LC (method 2): tR=1.27 min; Mass spectrum (ESI+): m/z=434 [M+H]+.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US08822471B2uspto-grants-2014_09