Реакция #155910

Уравнение реакции

3-methyl-1-phenyl-6-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one hydrochloride

tert-butyl 3-oxopyrrolidine-1-carboxylate

NaBH3CN

→

tert-butyl 3-(4-(3-methyl-4-oxo-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)piperidin-1-yl)pyrrolidine-1-carboxylate

Растворители

methanol

Условия реакции

Обработка

1. 1
   ДругоеInto a 100-mL round-bottom flask, was placed
2. 2
   Другоеat room temperature
3. 3
   Другоеat room temperature
4. 4
   КонцентрированиеThe resulting mixture was concentrated under vacuum
5. 5
   workup.DISSOLUTIONThe residue was dissolved in water (50 mL)
6. 6
   ЭкстракцияThe resulting solution was extracted with ethyl acetate (3×50 mL)
7. 7
   Концентрированиеconcentrated under vacuum

Методика

Into a 100-mL round-bottom flask, was placed a solution of 3-methyl-1-phenyl-6-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one hydrochloride (500 mg, 1.45 mmol, 1.00 equiv) in methanol (50 mL) at room temperature. To the resulting mixture was then added tert-butyl 3-oxopyrrolidine-1-carboxylate (804 mg, 4.35 mmol, 3.00 equiv), in portions at room temperature, followed by NaBH3CN (456 mg, 7.24 mmol, 5.00 equiv) at room temperature. The resulting solution was stirred overnight at room temperature. The resulting mixture was concentrated under vacuum. The residue was dissolved in water (50 mL). The resulting solution was extracted with ethyl acetate (3×50 mL), the organic layers combined and concentrated under vacuum to yield tert-butyl 3-(4-(3-methyl-4-oxo-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)piperidin-1-yl)pyrrolidine-1-carboxylate as a white solid.

Источник