Реакция #155569

Уравнение реакции

sodium hydride

2-bromo-1,1-diethoxyethane

(2R)-1-(benzyloxy)pent-4-en-2-ol

→

product

Выход 51.0%

({[(2R)-2-(2,2-diethoxyethoxy)pent-4-en-1-yl]oxy}methyl)benzene

Выход 51.0%

Растворители

tetrahydrofuran

tetrahydrofuran

tetrahydrofuran

Условия реакции

Обработка

1. 1
   Температураwhile the reaction temperature was maintained below 30° C
2. 2
   Температураthe temperature was gradually increased to 70° C.
3. 3
   workup.WAITthe reaction mixture was left
4. 4
   workup.STIRRINGto stir at 70° C. for 18 hours
5. 5
   ТемператураIt was then cooled to room temperature
6. 6
   Температураsubsequently cooled in an ice bath
7. 7
   Другоеquenched by slow addition of ice/water (200 mL)
8. 8
   Другоеat approximately 18° C
9. 9
   ДругоеThe mixture was partitioned between saturated aqueous sodium chloride solution (1 L) and ethyl acetate (1 L)
10. 10
    Промывкаthe organic layer was washed with saturated aqueous sodium chloride solution (1 L)
11. 11
    Сушкаdried over magnesium sulfate
12. 12
    Фильтрацияfiltered
13. 13
    Концентрированиеconcentrated under reduced pressure
14. 14
    ДругоеPurification
15. 15
    Фильтрацияwas effected by filtration through a pad of silica (Gradient: 0% to 20% ethyl acetate in heptane)

Методика

To a suspension of sodium hydride (60% in mineral oil, 98.8 g, 2.47 mol) in tetrahydrofuran (1 L) at room temperature was added drop-wise over 30 minutes a solution of (2R)-1-(benzyloxy)pent-4-en-2-ol (C1) (190 g, 0.988 mol) in tetrahydrofuran (500 mL), while the reaction temperature was maintained below 30° C. After 30 minutes, a solution of 2-bromo-1,1-diethoxyethane (390 g, 1.98 mol) in tetrahydrofuran (500 mL) was added drop-wise. The reaction mixture was stirred at room temperature for 1 hour, then the temperature was gradually increased to 70° C. and the reaction mixture was left to stir at 70° C. for 18 hours. It was then cooled to room temperature, subsequently cooled in an ice bath, and quenched by slow addition of ice/water (200 mL), while keeping the internal reaction temperature at approximately 18° C. The mixture was partitioned between saturated aqueous sodium chloride solution (1 L) and ethyl acetate (1 L), and the organic layer was washed with saturated aqueous sodium chloride solution (1 L), dried over magnesium sulfate, filtered, and concentrated under reduced pressure. Purification was effected by filtration through a pad of silica (Gradient: 0% to 20% ethyl acetate in heptane) to afford the product as an orange oil. Yield: 257 g of 60% purity, approximately 500 mmol, 51% yield and 57.76 g of 90% purity, approximately 170 mmol, 17% yield. 1H NMR (400 MHz, CDCl3), product peaks only: δ 7.26-7.38 (m, 5H), 5.78-5.90 (m, 1H), 5.02-5.13 (m, 2H), 4.61 (t, J=5.3 Hz, 1H), 4.55 (s, 2H), 3.48-3.74 (m, 9H), 2.31-2.37 (m, 2H), 1.22 (t, J=7.1 Hz, 3H), 1.21 (t, J=7.1 Hz, 3H).

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