Реакция #155369

Уравнение реакции

1c

3-({3-[2-(4-Cyano-phenylamino)-acetylamino]-4-methylamino-benzoyl}-phenyl-amino)-propionic acid methyl ester

→

crude product

Выход 58.0%

3-({2-[(4-Cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-phenyl-amino)-propionic acid methyl ester

Выход 58.0%

Растворители

acetic acid

Условия реакции

Обработка

1. 1
   Температураto reflux for one hour
2. 2
   ДругоеThe solution was then evaporated to dryness
3. 3
   Другоеthe remaining solid triturated with water

Методика

A solution of the product of 1c (22.6 mmol) in 100 mL concentrated acetic acid was heated to reflux for one hour. The solution was then evaporated to dryness, the remaining solid triturated with water and under stirring the pH was adjusted to about 8-9. The crude product was isolated through extraction with ethyl acetate and purified by chromatography on silica gel (eluent: dichloromethane/ethanol 1:1).

Источник