Реакция #155319

Уравнение реакции

5-Methylbenzofuran-7-ylamine

ethanol

→

5-methyl-2,3-dihydrobenzofuran-7-ylamine

Выход 87.6%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   Другоеfollowed by conduction of catalytic reduction at room temperature under ordinary pressure
2. 2
   ДругоеThe catalyst was removed by celite filtration
3. 3
   Другоеcondensed under reduced pressure
4. 4
   Сушкаdried over anhydrous magnesium sulfate
5. 5
   Концентрированиеconcentrated to dryness under reduced pressure

Методика

5-Methylbenzofuran-7-ylamine (1.3 g, 8.8 mmol) and 10% palladium carbon (500 mg) were added to ethanol (50 ml), followed by conduction of catalytic reduction at room temperature under ordinary pressure. The catalyst was removed by celite filtration, and the obtained filtrate was condensed under reduced pressure. The residue was dissolved in dichloromethane, dried over anhydrous magnesium sulfate, and then concentrated to dryness under reduced pressure, giving a white powder of 5-methyl-2,3-dihydrobenzofuran-7-ylamine (1.15 g, yield: 87%).

Источник