Реакция #1552096
ord-a6a464bc15c64a77bc0deb519121c184
Уравнение реакции
3-(3,3-dimethylbutyl)cyclohexanamine
3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carbonyl chloride
→
3-(difluoromethyl)-N-[3-(3,3-dimethylbutyl)cyclohexyl]-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide
Выход 54.0%
Реактанты
Реагенты
Нет
Условия реакции
Подробные условия
See reaction.notes.procedure_details.
Методика
As for example 1—step 6, condensation of 0.50 g 3-(3,3-dimethylbutyl)cyclohexanamine over 0.638 g of 3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carbonyl chloride gives 0.65 (54% of theory) of 3-(difluoromethyl)-N-[3-(3,3-dimethylbutyl)cyclohexyl]-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide. log P=4.80.