Реакция #1552041

Уравнение реакции

1-(3-dimethylamino propyl)-3-ethyl carbodiimide hydrochloride

phenylalanine

2-(phenylseleno)ethanol

THF

→

N-acetylphenylalanine 2-(phenylseleno)ethyl ester

Растворители

ethyl acetate

Условия реакции

Обработка

1. 1
   Экстракцияextracted with 50 ml of a 0.5 M HCl solution
2. 2
   СушкаThe organic phase was dried over sodium sulfate
3. 3
   Фильтрацияfiltered
4. 4
   Другоеthe solvent was removed in vacuo
5. 5
   ДругоеPurification by column chromatography (PE:EE=2:1)
6. 6
   Другоеyielded 2.9 g (91% of th., 98% of lit.) of a yellowish liquid

Методика

In a 50 ml round bottomed flask, 2.55 g (13.3 mmol) of 1-(3-dimethylamino propyl)-3-ethyl carbodiimide hydrochloride and 1.7 g of (8.2 mmol) phenylalanine were added to a solution of 1.87 g (9.3 mmol) of 2-(phenylseleno)ethanol in 20 ml of THF. The reaction mixture was then stirred for 12 hours at room temperature. The mixture was then diluted with 50 ml of ethyl acetate and extracted with 50 ml of a 0.5 M HCl solution. The organic phase was dried over sodium sulfate, filtered, and the solvent was removed in vacuo. Purification by column chromatography (PE:EE=2:1) yielded 2.9 g (91% of th., 98% of lit.) of a yellowish liquid.

Источник