Реакция #1552037

Уравнение реакции

palmitoyl chloride

N-hydroxysuccinimide

triethylamine

→

N-palmitoyloxy-Succinimide

Растворители

chloroform

Условия реакции

Обработка

1. 1
   ПромывкаAfter washed with 500 mL of water three times
2. 2
   Сушкаthe resultant solution was dried over magnesium sulfate
3. 3
   Концентрированиеwas then concentrated under reduced pressure
4. 4
   Другоеto obtain 260.3 g (quant) of a colorless solid

Методика

To a solution of 165 mL (0.544 mol) of palmitoyl chloride in 1 L of chloroform while cooled with ice with stirring, 69.8 g (0.598 mol) of N-hydroxysuccinimide was gradually added, and 83.1 mL (0.598 mol) of triethylamine was added dropwise thereto over 30 minutes. The resultant solution was stirred for 30 minutes while cooled with ice and for another 7 hours during which the resultant solution gradually reached room temperature. After washed with 500 mL of water three times, the resultant solution was dried over magnesium sulfate and was then concentrated under reduced pressure to obtain 260.3 g (quant) of a colorless solid.

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